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Acute abdomen - gallstone ileus

Gallstone ileus is an uncommon entity, which accounts for 1–4% of all presentations to hospital with small bowel obstruction and for up to 25% of all cases in patients over 65 years of age. Despite medical advances, gallstone ileus is still associated with high rates of morbidity and mortality. The management of gallstone ileus remains controversial. The clinical signs and symptoms of gallstone ileus are usually non-specific, contributing to a delay in diagnosis. We present our case admitted to the hospital with gallstone ileus.

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Genetické aspekty malígneho melanómu uvey

Identifikácia včasných diagnostických biomarkerov, ktorá umožní identifikáciu vysoko rizikových pacientov pred vznikom rozvinutých štádií ochorenia umožní ich cielenú, personalizovanú liečbu.

Rozvojom nových metód v oblasti cytogenetiky a molekulovej biológie sa veľmi rýchlo rozrastajú poznatky o chromozómových abnormalitách, molekulových zmenách a regulátoroch bunkového cyklu. Viaceré chromozómové abnormality a zmeny v regulátoroch bunkového cyklu predstavujú významné prognostické faktory MMU.

Práca uvádza poznatky o základoch alterácie génov, proteínov, signálnych dráh súvisiacich s malígnou transformáciou bunky, chromozómových abnormalitách, informáciu o epigenetickej deregulácii expresie tumor-supresorových génov a génov podieľajúcich sa na procesoch metastázovania.

 Podporené grantom KEGA 008-UK - 4/2014

Occupational musculoskeletal diseases: multimedia guide for the English programme students

This multimedia guide is especially meant for teaching Occupational medicine in the master degree programme General Medicine in English. Illustrative and comprehensive processing of the theme of musculoskeletal diseases is aimed at a more detailed introduction into these up-to-date problems.
Except for the most frequent upper extremity diseases caused by the exposure to hand-treansmitted vibration and overload, disorders of the vertebral column and lower extremities are discussed. Furthermore, occupational diseases assessment systems of other countries, expecially of those from which the foreign students come from, are mentioned. Case-reports, an English-Czech glossary of occupations and a test of knowledge are included. Short-form videos directly from the workplaces, such as stome quarries, foundries, assembly lines, medical or artistic working environments show operations which can lead to health disturbances.
We hope that the readers will enjoy the opportunity of comfortable studying the discipline in the FlipViewer technology.